HEAT SHOCK PROTEIN 70 AND EXERCISE: MORPHOFUNCTIONAL RELATIONSHIPS

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The expression of Heat Shock Proteins (HSPs) is one of the most defensive mechanism against cellular stress, HSPs are an heterogeneous family of molecules highly maintained across the species during the evolution. Exercise training represents the most important source of stress in the skeletal muscle and it triggers the increase of the expression of HSPs, particularly Hsp70, into the cells, plays the intracellular role of chaperone and stress sensor. It has been shown that the expression of Hsp70 as cell re- sponse to stress is directly proportional to stress intensity. Several authors described Hsp70 trends as result of diffe- rent training protocols in both human and animal skeletal muscles, getting out contrasting results. The purpose of this review is to clarify the influence of exercise on the production of Hsp70. Further experiments are necessary to understand better the Hsp70 role in damage induced by physical training to schedule an optimal workout program.
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