PROTEIN KINASES AND PHOSPHATASES AS DRUG TARGETS TO CURE HUMAN MALIGNANCIES 0 By Manlio Vinciguerra on March 18, 2008 Capsula eBurnea Protein phosphorylation controls various aspects of cell proliferation, differentiation, metabolism, survival and motil- ity. Protein kinases and phosphatases are involved in intra- cellular signal transduction pathways providing a dynamic and reversible regulation of many biological activities. One of the biggest challenges of modern medicine is to identify promising therapeutic targets among these families of en- zymes, which are involved in the development of various human cancers. This review focuses on protein kinases and phosphatases as targets of small-molecule drugs. Some examples of breakthrough compounds are highlighted to illustrate achievements and challenges in the generation of small- molecule inhibitors to cure human malignancies. Share. Twitter Facebook Google+ Pinterest LinkedIn Tumblr Email
December 31, 2011 0 SCAR REVISION PRINCIPLES APPLIED TO EXCISIONAL,IRREGULARIZATION & V-TO-Y ADVANCEMENT FLAP TECHNIQUES
December 31, 2011 0 THE ROLE OF FENTANYL CITRATE DURING ADJUVANT RADIATION THERAPY FOR BONE METASTASES
