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Tuesday, 11 April 2017 08:04

ACETYL-L-CARNITINE AFFECTS THE ELECTRICAL ACTIVITY OF MECHANOSENSORY NEURONS IN HIRUDO MEDICINALIS GANGLIA

Written by Giovanna Traina et al.
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Was previously discovered that in the leech Hirudo medicinalis, acetyl-l-carnitine (ALC) affects forms of

non-associative learning, such as sensitization and dishabituation, due to nociceptive stimulation of the

dorsal skin in the swim induction behavioural paradigm, likely through modulating the activity of the

mechanosensory tactile (T) neurons, which initiate swimming. Since was found that ALC impaired

sensitization and dishabituation, both of which are mediated by the neurotransmitter serotonin, the present

study analyzed how ALC may interfere with the sensitizing response.

Was already found that ALC reduced the activity of nociceptive (N) neurons, which modulate T cell

activity through serotonergic mediation.

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