Was previously discovered that in the leech Hirudo medicinalis, acetyl-l-carnitine (ALC) affects forms of
non-associative learning, such as sensitization and dishabituation, due to nociceptive stimulation of the
dorsal skin in the swim induction behavioural paradigm, likely through modulating the activity of the
mechanosensory tactile (T) neurons, which initiate swimming. Since was found that ALC impaired
sensitization and dishabituation, both of which are mediated by the neurotransmitter serotonin, the present
study analyzed how ALC may interfere with the sensitizing response.
Was already found that ALC reduced the activity of nociceptive (N) neurons, which modulate T cell
activity through serotonergic mediation.