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Wednesday, 19 April 2017 10:03

POSSIBLE RELATED FUNCTIONS OF THE NON-HOMOLOGOUS CO-REGULATED GENE PAIR PDCD10 AND SERPINI1

Written by Concetta Scimone
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Gene expression in mammalians is a very finely controlled mechanism, and bidirectional promoters can be

considered one of the most compelling examples of the accuracy of genic expression coordination. As

recently reported, a bidirectional promoter regulates the expression of the PDCD10(whose mutations

cause familial Cerebral Cavernous Malformations (CCMs) and SERPINI1 gene pair, even though they are

non-homologous genes. The aim of this study was to identify any potential common roles of these two coregulated

genes. An in-silico approach was used to identify functional correlations, using the BioGraph,

IPA® and Cytoscape tools and the KEGG pathway database. The results obtained show that PDCD10 and

SERPINI1 may co-regulate some cellular processes, particularly those related to focal adhesion

maintenance. All common pathways identified for PDCD10 and SERPINI1 are closely associated with the

pathogenic characteristics of CCMs; we thus hypothesize that genes involved in these networks may

contribute to the development of CCMs.

Read 47 times Last modified on Wednesday, 19 April 2017 11:23
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