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Wednesday, 19 April 2017 10:11

APOPTOSIS RATE IN CUMULUS CELLS AS POSSIBLE MOLECULAR BIOMARKER FOR OOCYTE COMPETENCE.

Written by Liana Bosco et al
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Several lines of evidence showed that apoptosis rate of cumulus cells in oocytes derived by assisted

reproductive technologies could be used as an indicator of fertilizing gamete quality. Aim of the study

was to investigate the effects of three different ovarian stimulation protocols on the biological and clinical

outcome in hyporesponder patients. Collected data showed a higher significant rate of DNA fragmentation

index (DFI) in U group (patients treated with Highly Purified human Menopausal Gonadotrophin) than in

P group (treated with recombinant human Follicle Stimulating Hormone (r-hFSH) combined with

recombinant human Luteinizing Hormone (r-hLH)). Both groups R (treated with r-hFSH alone) and P

showed a significant increase in collected and fertilized oocytes number, embryo quality number. This

study showed that combined r-hFSH/r-hLH therapy could represent the best pharmacological strategy for

controlled ovarian stimulation and suggests to use DFI as a biomarker of ovarian function in

hyporesponder patients.

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