In the senile population, regular physical activity and reduction of a sedentary lifestyle lead to a series of positive effects. Such as, increased independence in daily activities and personal care, higher self-esteem, a better quality of life, a higher life expectancy and a decrease in mortality. Moreover, physical, psychological, and cognitive functions can also improve. With regards to this notion, the Walking Football (WF) activity was started in England; a sport designed for the needs population segment, who, due to overweight and other typical diseases of old age, has a limited mobility and can only play sports with lowmoderate cardiovascular effort. WF is a new sport mainly created for people over 50, i.e. the population diagnosed with chronic degenerative diseases, and the actual increase of obesity gradually cause to abstain from a regular physical activity. The game is played 7 vs. 7 and all players must only walk; running is considered a foul. To avoid sudden movements and reduce the risk of injury, the ball must be always kept on the ground, and slide tackles and an aggressive behavior are prohibited. This sport, a slow variation of football, is considered a low risk sport activity for the low incidence of traumatic events and can be practiced safely because the cardiovascular effort is minimum. WF comes directly from football, which is considered the most popular sport in the world. It is also associated with positive social and motivational factors that may facilitate compliance to the sport, which help maintain a physically active lifestyle. WF is still not widespread in Italy, and our hope is that it can become, in a short time, a reference for the sports designed for the elderly.
COLON MICROBIAL COMPOSITION IS CORRELATED WITH THE SEVERITY OF COLITIS INDUCED BY 2,4,6-TRINITROBENZENESULFONIC ACID IN MICEWritten by Giovanna Traina et al.
The objective of this study was to evaluate the changes in some bacterial species of colonic microbiota, the clinical signs and the intestinal changes in mice with 2,4,6trinitrobenzenesulfonic acid (TNBS)-induced colitis. CD-1 male mice were randomly divided into three groups and inoculated intrarectally with saline, ethanol or TNBS solutions. Ethanol and TNBS treatments induced weight loss accompanied by mild and severe inflammation of the colon mucosa, respectively. However, TNBS-treated mice displayed significant differences compared to the saline group in terms of disease activity index and histological scoring. Both ethanol and TNBS groups showed an increased prevalence of Escherichia coli and Clostridium spp., a decrease in Lactobacilli and Bifidobacteria counts, as well as changes in the relative proportions of bacteria in the colon. The results confirm the validity of TNBS treatment to study the mechanisms involved in the pathogenesis and progression of inflammatory bowel diseases (IBD) in CD-1 mice. Gut microbiota may become a diagnostic biomarker with therapeutic potential for IBD in the future.
Reduction mammoplasty is one of the most common procedures performed by plastic surgeons. Surgeons select the technique that best suits each patient based on the surgeon’s experience, specific patient characteristics and requirements. The purpose of this article is to report the complications that occurred in patients who underwent reduction mammoplasty at our institution, and to compare our data to the current literature. We studied the postoperative complications from 82 breast reductions (41 patients), which used superior pedicle (n = 6), inferior pedicle (n = 36), medial pedicle (n = 10) or Thorek (n = 30) techniques. The most common postoperative complications were hematoma (7%), seroma (2.5%), delayed wound healing (14%), partial nipple loss (4.8%), infection (10%) and asymmetry (12%). We observed complications in 64% of patients that underwent inferior pedicle breast reduction with an inverted T scar. One possible explanation for this complication rate is that inferior pedicle Wise-pattern mammoplasty is usually performed for breasts with sternal notch-tonipple distances greater than 32 cm, or for symptomatic macromastia, and greater amounts of resected tissue are known to be associated with higher complication rates. Nevertheless, this technique is associated with excellent patient satisfaction. Indeed, complications are quite frequent and may occur even in the most suitable candidates, but do not compromise the final result.
PREVALENCE AND RISK FACTORS OF EXTENDED SPECTRUM BETA LACTAMASE ORGANISMS IN COMMUNITY-ACQUIRED URINARY TRACT INFECTIONS IN LEBANON: A CASE CONTROL STUDYWritten by Elie El-Hajj et al.
In Lebanon, clinical information about community-acquired urinary tract infections (CAUTI) caused by extended-spectrum beta-lactamase (ESBL)-producing Gram negative bacteria (GNB), is scarce. A population based case-control study was conductedwhereby42 cases were matched to 42 controls. The prevalence of ESBL producing strains was 14.15%. Univariate analysis showed two statistically significant independent risk factors for ESBL producing strains: antibiotic use during the last three months (p<0.0001), and urinary catheterization during the last six months (p=0.0034); and one protective factor: age group 18-50 years (p=0.011). Multivariate analysis showed antibiotic use as the strongest predictor for CAUTI due to ESBL-producing GNB. Coresistance of ESBL producing strains to antibiotics was significantly higher compared with non ESBL strains: ciprofloxacin (75% vs 21.4%), trimethropin-sulfamethoxazole (71.1% vs 35.7%) and amoxicillin-clavulanate (77.7% vs 9.5%).This study confirms that ESBL-producing GNB strains constitute a notable cause of CAUTI in Lebanon. These results can be used to guide appropriate treatment of CAUTI and targeted infection control measures
Introduction. This study aimed to analyze the influence of Platelet-Rich Plasma (PRP) on bone growth in experimental instrumented interbody spinal fusion (IISF).
Methods. 16 adult sheep underwent IISF at L3–L4 level using a cylindrical threaded expanding titanium cage with morselized iliac crest cancellous autograft. In 8 animals (Group I) this was augmented with PRP, in the remaining 8 (Group II), it was not. Ra-diographs of the spine were taken preoperatively and at 1, 3, and 6 months, moreover autoptic vertebral samples were obtained and evaluated histologically and by CT scan at 8 months.
Results. Histological analysis revealed more evident new bone formation with bony bridge into the cages in Group I than Group II. There were relevant differences be-tween the groups with regard to interbody fusion calculated using trabecular bone score (p<0.05).
DISCRIMINATING DIABETIC PTs OF SOME RURAL & URBAN AREAS OF BANGLADESH:DISCRIMINANT ANALYSIS APPROACHWritten by Jannatul Fardus et al.
The present analysis was conducted in the American International University of Bang-ladesh using the data collected from 900 respondents. Among the respondents 70.6 percent are diabetic patients. Finding reveals that the largest percentage of patients is of the age group ≥ 50+ years. About 34 percent patients are suffering from Type II diabetes and among them 63.3 percent are in the age group ≥50+ years. Higher prevalence rates of diabetes are observed among farmers and retired persons. The diabetic patients are discriminated from non-diabetic respondents due to the variables age, residence and work type. Most important variables for discriminating diabetic pa-tients are age, education and work-type.
The tumour of Warthin (WT) is the second parotid tumour for frequency after the pleomorphic adenoma, it represents about 2% to 15% of all parotid tumors. The pathogenesis of familial Warthin Tumour is unknown, even if cytogenetic abnormali-ties have been identified in Warthin Tumour. Among the inducing factors there is the smoke which has an important role. Familial occurrence of Warthin Tumour is rare, only five reports in the literature. Two of them were reported in brothers, two in a mother and son and one in monozygotic twins. We quote a case of familiar Warthin Tumour arisen in two brothers and we present a review of the Literature.
Nutraceuticals constitute a group of functional foods that provide added health bene-fits for various disorders including inflammatory bowel disease (IBD) and colorectal cancer (CRC). The main groups of nutraceuticals include probiotics, prebiotics, omega 3 and antioxidants. Studies on Nutraceutical showed that this type of food possessed similar proprieties to drugs but with the benefit of not having side effects.
This mini review shows that probiotics and prebiotics, when administered simultane-ously with traditional therapies, reduce IBD symptoms and reduce synthesis of en-zymes probably involved in colorectal carcinogenesis. Moreover, Omega 3 reduces the synthesis of inflammation mediators and prevents carcinogenesis through interaction with the signaling pathway NOTCH1/MMP9. Moreover, antioxidants reduce the inflam-matory process by inhibiting the synthesis of inflammatory mediators, and inhibit the mechanisms of cell proliferation by inducing apoptosis.
In brief, nutraceuticals have gained a huge clinical interest since they could be used along with traditional therapy. Bioavailability studies of nutraceutical supplements guarantee a correct intake of the substance by oral administration, a matter which would not have been possible to have entirely with the consumption of regular food only.
Prune Belly Syndrome (PBS) is a rare congenital syndrome characterized by three main features: abdominal wall flaccidity, bilateral intra-abdominal cryptorchidism, and urologic abnormalities.
In this study we describe the case of a 2,600 gr baby, born at the Central Hospital of Beira, Mozambique.
Our study confirms that in a low-income country only conservative management can be delivered, and therefore prognosis is worse and less effective than high-income countries.
The intestinal inflammatory bowel disease (IBD) are a group of inflammatory patholo-gies of the digestive line with chronicity and recurrent characteristics. The IBDs mostly recognized are the ulcerative colitis and Crohn’s disease; they are more frequent in the industrialized countries and among the caucasian populations that among those africans or oriental. The secondary artropaties to IBD recognize a multifactorial gene-sis in subjects predisposed as a result genetically of environmental factors; a funda-mental role of the intestinal dysbiosis they are hypothesized.
A 16-year-old girl had been undergoing intensive chemotherapy (ALL 2009) for Early T -cell precursor acute lymphoblastic leukemia (ETP). At 22:00 of the 26th day of induc-tion phase IA, she was found to have developed febrile neutropenia. After blood cul-tures were obtained, empirical therapy with ceftriaxone and amikacin was initiated, according to internal protocol. Clinical condition improved and she remained afebrile for 24 hours. The following day, at 04:00, she suddenly developed a cough with hemoptysis. At this time, fibrinogen was 167 mg/dL, and platelets 35000/uL. A chest X-ray showed thickening in the middle of the right lower zone, and a chest CT scan showed a nodule with central hypodense area (necrotic-colliquative evolution of the infiltrate). In spite of supplementation with platelets, red blood cells, plasma, fibrino-gen, antithrombin, and activated factor VII, the patient's clinical condition worsened rapidly and the pulmonary hemorrhage became uncontrollable. She died at 12:00. Blood cultures yielded a strain of Pseudomonas aeruginosa, with reduced sensitivity to antibiotics.
Aspergillosis is the most frequent infectious cause of massive pulmonary hemorrhage in pediatric leukemias, while bacterial pneumonia or TBC are by far less frequent. As-pergillus requires the presence of neutrophils to cause hemoptysis or cavitation, while bacteria (Gram-positive or -negative) can cause pulmonary necrosis also in patients with neutropenia.