Methyldibromoglutaronitrile (MDBGN) is a preservative found in cosmetics as well as in products for industrial use. It caused an outbreak of allergic contact dermatitis in Europe in the 1990s and early 2000s. To assess the prevalence of MDBGN sensitization among consultants in the occupational dermato-allergology unit of Farhat Hached University Hospital in Sousse-Tunisia, we carried out a study of all cases of contact dermatitis to MDBGN confirmed by patch-tests from 1 January 2011 to 31 December 2015. The prevalence of allergic contact dermatitis to MDBGN was 4.5% of all cases of contact dermatitis recorded during the same period with an increase from 1.7% in 2011 to 5.4% in 2015. Associated allergens with contact dermatitis to MDBGN were the Peru balsam in 4 cases, nickel sulfate and kathon CG in 3 cases each. Contact dermatitis to Dibromodicyanobutane was associated with sensitization to other preservatives in 4 cases and cosmetic allergens in 6 cases. An increasing rates of sensitization are noticed in our region. The absence of legal restrictions regarding this preservative agent may explain an increase of its use in non-European countries.
Respiratory Epithelial Adenomatoid Hamartoma (REAH) is a rare benign lesion that may occur in the nasal cavity and paranasal sinuses. Histology is essential for the differential diagnosis with other lesions that could affect the sinonasal region. Our report focuses on three cases of male patients that were 46, 66 and 73 years old, diagnosed with REAH of the sinonasal region. All cases presented a nasal obstruction and hyposmia, and in one case cephalalgia. The definitive diagnosis of REAH was supported by the endoscopic, radiological and histological examinations. The patients underwent surgical excision with an endoscopic approach and did not experience a local recurrence at the time of writing this manuscript. REAH is a rare and often unrecognized clinical condition. The gold standard for treatment is complete surgical excision, which also allows for a correct histological diagnosis. Recurrence after surgery was not reported in our findings, as described in the literature.
The current study aimed to explore the relationships between metacognition and anxiety, depression, and coping strategies in MS patients, compared to healthy subjects. The study was conducted on a group of 50 MS patients and a control group of 50 healthy volunteers matched for gender, age, level of education and social status. Metacognitions were assessed with the Metacognitions Questionnaire-30, while anxiety and depression were assessed with the Hospital Anxiety and Depression Scale, and coping strategies were assessed with the Brief COPE. Results did not show significant differences between metacognitive factors for MS patients and healthy subjects. However, we found specific, contrasting correlations between the MS group and the control group. The results of this study could have some implications for clinical practice. Given the relationship between metacognitions and negative emotions, “psychological intervention”, based on the metacognitive approach, could have positive effects on MS patients.
Corruption affects healthcare effectiveness and efficiency and limits equity in access to health services. Aim of the survey was to document knowledge and viewpoints on the impact of corruption on healthcare system in a sample of students attending pre-lauream healthcare professional courses at Palermo University Medical school and to evaluate any improvement in their awareness on this topic after a dedicated multidisciplinary educational intervention. An anonymous questionnaire was administered to students before and after the intervention. Absolute and relative frequency of correct and incorrect answers was computed. Chi-squared test was used to compare answers given before and after the educational intervention. Approximately less than a quarter of the respondents were able to correctly estimate impact of corruption, inappropriateness and waste in healthcare on NHS. The study documented how improving students’ knowledge of the impact of corruption in the healthcare system could represent a possible strategy to prevent corruption in healthcare.
Pleomorphic adenoma is the most common benign tumor of the salivary glands. It arises mainly from the parotid, less frequently from the minor salivary glands of the oral cavity and, exceptionally, from the accessory glands widespread in the upper aero-digestive tract. Intranasal localization is rare and mainly affects the glands sited in the nasal septal mucosa. There are isolated case reports in literature regarding adult patients. We report a rare case of a young 14-year-old girl with pleomorphic adenoma arising from the nasal septum.
We present our experience in the treatment of fractures of the tibial plateau with arthroscopic assistance. Between January 1997 and September 2001, we evaluated 23 patients with fractures of the tibial plateau. After their clinical and radiological evaluation, we included 17 patients in this study. Fractures were classified using the Schatzker classification. 14 patients were treated with arthroscopic reduction and percutaneous fixation, while 3patients underwent open reduction and osteosynthesis with platelets under arthroscopic control. The arthroscopic technique allows for a better articular visualization, decreases dissection of the tissues, and allows for an adequate diagnosis and treatment of the associated lesions. Arthroscopic reduction and percutaneous fixation can be considered the treatment of choice in a select group of fractures of the tibial plateau (Schatzker I and III).
Currently, surgical training of physicians in Italy has limited possibilities.Surgical training can be performed on dissection of human bodies as well as in animal laboratories, but experience is very poor. We conducted a survey through an anonymous questionnaire in order to evaluate the opinions of post-graduate physicians on their need for experience training on both human and animal bodies during their medical studies. A total of 165 young Sicilian physicians responded to the survey. Only 14 of them (8.5%) declared they had specific training on a live animal, while 46 (27.9%) reported they already attended cadaver labs. Over 70% assigned the maximum score to the utility of such courses as integration of medical academic offer. Our results showed that the majority of the subjects interviewed expressed a need for training using these practices and that it might be necessary to investigate patterns to promote the opportunity for direct practice on human and animal bodies.
Little is known about the relationship between laryngopharyngeal reflux (LPR) and periodontal or dental lesions. This study investigates the association of dental and periodontal involvement in patients with LPR compared to a control group. A prospective study was carried out on 102 patients complaining of LPR symptoms. The authors used the Reflux Symptom Index (RFS), Reflux Findings Score (RSI) and 24-h ambulatory pH monitoring to diagnose LPR disease. Two study groups were established, the LPR group included patients with LPR diagnosis and a control group selected from excluded patients. All patients underwent an oral examination for the evaluation of dental and periodontal status. Plaque index, gingival index and hemorrhage index were collected too. LPR was revealed to be associated with both an increased incidence of chronic periodontitis with significantly higher values of plaque index (p=0.018), hemorrhage index (p=0.048) , gingival recession (p=0.039) and higher tooth wear scores when compared to those of the control group. We support the view that laryngopharyngeal reflux might play a considerable role in the manifestation of periodontal and dental lesions.
This paper is a retrospective study examining 328 cadavers deceased from traffic accidents (252 drivers and 76 front seat passengers). Specifically, the skeletal injuries of the cranial, spine, chest, upper and lower limbs were examined. The purpose of the study is to ascertain whether it is possible to identify, through the skeletal injury patterns, who was driving at the time of the traffic accident. A statistical analysis was used to detect injuries that could differentiate between driver and front passenger. Drivers more frequently reported chest injuries, especially sternal injuries, due to the collision with the steering wheel. On the other hand, front passengers more frequently reported skull and spinal injuries. Furthermore, a greater incidence of pelvis fractures in front passengers was observed compared to drivers. The chest injury pattern resulted to be the most effective for distinguishing the driver from the front passenger.
The aims of the present study were to determine the association between IGF-1gene polymorphism with obese individuals. This case– control analysis was performed on 50 subjects ,obese (n=30) and control (n=20) groups for age ranged (20-40 year).The results showed that genotype distribution of AA and AB in IGF-1 gene polymorphism were 83.3% and 16.7% respectively in the patients of obese group, while it was 90.0% and 10.0% respectively in the control group .Meantime the allele frequency of A and B in IGF-1 gene polymorphism were 91.65% and 8.35% respectively in obese group, whereas it was 95.0% and 5.0% respectively in the control group. Several single nucleotide polymorphisms (SNPs), was obtained between the two resolved haplotypes and between the IGF1 gene, exon3 Primer3 plus reference of the study. The results demonstrate that there is no association between AA and AB polymorphisms with in obese (OR=0.87,CI[0.71-1.17]) as in comparison with control groups.