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Gene expression in mammalians is a very finely controlled mechanism, and bidirectional promoters can be

considered one of the most compelling examples of the accuracy of genic expression coordination. As

recently reported, a bidirectional promoter regulates the expression of the PDCD10(whose mutations

cause familial Cerebral Cavernous Malformations (CCMs) and SERPINI1 gene pair, even though they are

non-homologous genes. The aim of this study was to identify any potential common roles of these two coregulated

genes. An in-silico approach was used to identify functional correlations, using the BioGraph,

IPA® and Cytoscape tools and the KEGG pathway database. The results obtained show that PDCD10 and

SERPINI1 may co-regulate some cellular processes, particularly those related to focal adhesion

maintenance. All common pathways identified for PDCD10 and SERPINI1 are closely associated with the

pathogenic characteristics of CCMs; we thus hypothesize that genes involved in these networks may

contribute to the development of CCMs.

Published in Embj

The practice of sport, intended not just as a physical activity performed exclusively for athletic

competition, represents a key element for growth on an emotional and social level. Practicing sports can

help to enhance one’s self- and body awareness through multidimensional dynamic and ludic activity. In

this context, sport becomes an educational and training tool, and is often a forerunner of social change.

Sports practice combining physical activity with recreational activity, can, in fact, promote health and

longevity, as well as physical and psychological wellbeing. As highlighted by the European Union, sport

is also a source of social inclusion, and an excellent tool for the integration of minorities and groups at risk

of social exclusion.

Published in Embj

The oculomotor nucleus is divided into: 1. somatic medial column innervating the superior rectus muscle and somatic lateral column, further subdivided into a lateral column innervating the inferior rectus, inferior oblique and medial rectus muscles; 2. central nucleus innervating the levator palpebrae superioris muscle; 3. visceral nucleus innervating the pupillary sphincter muscle, consisting of the following two groups of neurons: cholinergic, preganglionic neurons supplying the ciliary ganglion, termed the Edinger-Westphal preganglionic (EWpg) neuron population, and the centrally projecting, peptidergic neurons, termed the Edinger-Westphal centrally projecting (EWcp) population. A detailed understanding of the position of both nuclei and their subgroups supplying the individual muscles is an essential prerequisite for eye movement assessment, offering a simple clinical method for diagnosing eventual dysfunctions of eye movement generation pathways.

Published in Embj
Published in Embj

The use of image analysis methods has allowed us to obtain more reliable and reproducible immunohistochemistry (IHC) results. Wider use of such approaches and simplification of software allowing a colorimetric study has meant that these methods are available to everyone, and made it possible to standardize the technique by a reliable systems score. Moreover, the recent introduction of multispectral image acquisition systems methods has further refined these techniques, minimizing artefacts and easing the evaluation of the data by the observer. 


Published in Embj
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