Original Articles
Vol. 16 (2021)

BRUGADA PATTERN IN HEROIN ADDICTION: SYNDROME OR PHENOCOPY?

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Published: October 15 2025
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Authors

Ettore Mancia
Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties. Unit of Nephrology and Hypertension. European Society of Hypertension Excellence Center. University of Palermo, Italy., Italy.
Caterina Carollo
Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties. Unit of Nephrology and Hypertension. European Society of Hypertension Excellence Center. University of Palermo, Italy., Italy.
Laura Guarino
Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties. Unit of Nephrology and Hypertension. European Society of Hypertension Excellence Center. University of Palermo, Italy., Italy.
Marco Guarneri
Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties. Unit of Nephrology and Hypertension. European Society of Hypertension Excellence Center. University of Palermo, Italy., Italy.
Leonardo Calandra
Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties. Unit of Nephrology and Hypertension. European Society of Hypertension Excellence Center. University of Palermo, Italy., Italy.
Santina Cottone
Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties. Unit of Nephrology and Hypertension. European Society of Hypertension Excellence Center. University of Palermo, Italy., Italy.
Giuseppe Mulè
giuseppe.mule@unipa.it
Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties. Unit of Nephrology and Hypertension. European Society of Hypertension Excellence Center. University of Palermo, Italy., Italy.
Gregory Dendramis
Division of Cardiology, clinical and interventional arrhythmology. ARNAS Ospedale Civico Di Cristina Benefratelli, Palermo Italy, Italy.
Brugada phenocopies (BrPs) are clinical entities that show an electrocardiogram (ECG) pattern similar to what is observed in Brugada syndrome (BrS). They are caused by different clinical conditions. We describe a case of BrP in a man that developed acute kidney failure secondary to rhabdomyolysis, after heroin addiction. His initial ECG showed Brugada type 1 pattern resolved after hemodialytic treatment. A provocative test with ajmaline, which resulted negative, was performed to confirm the diagnosis. BrPs can mimic a true BrS and a fast recognition of these clinical and electrocardiographic findings may avoid diagnostic mistakes thus preventing unnecessary or inaccurate treatments

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BRUGADA PATTERN IN HEROIN ADDICTION: SYNDROME OR PHENOCOPY?. (2025). EuroMediterranean Biomedical Journal, 16. https://doi.org/10.3269/ebmj.2021.101
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