Case Reports Open access

CONGENITAL NEUROBLASTOMA: A RARE CASE OF PLURIVISCERAL METASTATIC DISSEMINATION

Authors

  • Ginevra Malta – articles in this journal Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, Section of Legal Medicine, University of Palermo, Palermo, Italy, Italy.
  • Chiara Rizzo – articles in this journal Corresponding author Email Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, Section of Legal Medicine, University of Palermo, Palermo, Italy, Italy.
  • Corinne La Spina – articles in this journal Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, Section of Legal Medicine, University of Palermo, Palermo, Italy, Italy.
  • Emiliano Maresi – articles in this journal Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, Section of Legal Medicine, University of Palermo, Palermo, Italy, Italy.
  • Stefania Zerbo – articles in this journal Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, Section of Legal Medicine, University of Palermo, Palermo, Italy, Italy.
  • Antonina Argo – articles in this journal Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, Section of Legal Medicine, University of Palermo, Palermo, Italy., Italy.
Published
15 October 2025
Section
Case Reports
DOI
10.3269/1970-5492.2021.16.23

Abstract

Neuroblastoma is one of the most common neonatal tumors. It involves children in early infancy
and originates from neural crest cells of the adrenal gland medulla or sympathetic glia. We report
an unusual case of congenital poorly differentiated neuroblastoma with multiple metastases in the
brain and cerebellum. The biophysical profile showed a prominent polyhydramnios at 25.3 weeks
of gestation; meantime, the mother was diagnosed with gestational diabetes. The mass was detected
during the third ultrasonographic examination at 31.4 weeks of gestation. The fetus lived only one
day after birth and the postmortem examinations were performed subsequently. An autopsy was
performed both to understand the causes of death and to identify any profiles of professional
responsibility. The histological examination confirmed the diagnosis: a neoplasm arising from the
lower right limb and pelvis.

Metrics

Citations and online attention from Dimensions, Altmetric and PlumX.

PlumX Metrics

License

Copyright (c) 2025 The Author(s)

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.