Case Reports
Vol. 16 (2021)
https://doi.org/10.3269/1970-5492.2021.16.23

CONGENITAL NEUROBLASTOMA: A RARE CASE OF PLURIVISCERAL METASTATIC DISSEMINATION

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Received: October 14 2025
Published: October 15 2025
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Authors

Ginevra Malta
Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, Section of Legal Medicine, University of Palermo, Palermo, Italy, Italy.
Chiara Rizzo
chiara.rizzo01@you.unipa.it
Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, Section of Legal Medicine, University of Palermo, Palermo, Italy, Italy.
Corinne La Spina
Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, Section of Legal Medicine, University of Palermo, Palermo, Italy, Italy.
Emiliano Maresi
Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, Section of Legal Medicine, University of Palermo, Palermo, Italy, Italy.
Stefania Zerbo
Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, Section of Legal Medicine, University of Palermo, Palermo, Italy, Italy.
Antonina Argo
Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, Section of Legal Medicine, University of Palermo, Palermo, Italy., Italy.
Neuroblastoma is one of the most common neonatal tumors. It involves children in early infancy
and originates from neural crest cells of the adrenal gland medulla or sympathetic glia. We report
an unusual case of congenital poorly differentiated neuroblastoma with multiple metastases in the
brain and cerebellum. The biophysical profile showed a prominent polyhydramnios at 25.3 weeks
of gestation; meantime, the mother was diagnosed with gestational diabetes. The mass was detected
during the third ultrasonographic examination at 31.4 weeks of gestation. The fetus lived only one
day after birth and the postmortem examinations were performed subsequently. An autopsy was
performed both to understand the causes of death and to identify any profiles of professional
responsibility. The histological examination confirmed the diagnosis: a neoplasm arising from the
lower right limb and pelvis.

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CONGENITAL NEUROBLASTOMA: A RARE CASE OF PLURIVISCERAL METASTATIC DISSEMINATION. (2025). EuroMediterranean Biomedical Journal, 16. https://doi.org/10.3269/1970-5492.2021.16.23
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