Original Articles
Vol. 15 (2020)
https://doi.org/10.3269/1970-5492.2020.15.7

GAP JUNCTIONS, HEMICHANNELS AND CONNEXINS AND THEIR ROLE IN THE NEUROVASCULAR UNIT

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Received: October 15 2025
Published: October 16 2025
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Authors

Nunzio Vicario
nunziovicario@unict.it
Section of Physiology, Department of Biomedical and Biotechnological Science, University of Catania, Catania, Italy;, Italy.
Rosalba Parenti
Section of Physiology, Department of Biomedical and Biotechnological Science, University of Catania, Catania, Italy;, Italy.
Giovanni Li Volti
Section of Biochemistry, Department of Biomedical and Biotechnological Science, University of Catania, Catania, Italy;, Italy.
Recent advances have come to suggest that connexins (Cxs), the core gap junction (GJs) and
hemichannels (HCs) composing proteins, play a crucial role in neurodegenerative and
neuroprotective conditions. GJs and HCs syncytia in the complex neuroglial network allows glial
cells to support and even modulate neuronal function in both physiological and pathological
conditions. In this review we aim at reviewing the current knowledge in the context of neuroglial
crosstalk and neurovascular units (NVU) and at delivering up-to-date insights on cell populations
interplay in physiological and pathological central nervous system (CNS) conditions.

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GAP JUNCTIONS, HEMICHANNELS AND CONNEXINS AND THEIR ROLE IN THE NEUROVASCULAR UNIT. (2025). EuroMediterranean Biomedical Journal, 15. https://doi.org/10.3269/1970-5492.2020.15.7
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