Original Articles
Vol. 15 (2020)
https://doi.org/10.3269/1970-5492.2020.15.34

PLASMA LEVELS OF ANGIOGENIC AND ANGIOSTATIC FACTORS AFTER PANRETINAL PHOTOCOAGULATION FOR PROLIFERATIVE DIABETIC RETINOPATHY

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Received: October 16 2025
Published: October 16 2025
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Authors

Bhaskar Gaonkar
bskrgnkr@gmail.com
Department of Biochemistry, Kasturba Medical College Manipal, Manipal Academy of Higher Education, Manipal, India, India.
Krishnananda Prabhu
Department of Biochemistry, Kasturba Medical College Manipal, Manipal Academy of Higher Education, Manipal, India, India.
Pragna Rao
Department of Biochemistry, Kasturba Medical College Manipal, Manipal Academy of Higher Education, Manipal, India, India.
Asha Kamat
Department of Community Medicine, Kasturba Medical College Manipal, Manipal Academy of Higher Education, Manipal, India, India.
Krishna Rao
Department of Ophthalmology, Kasturba Medical College Manipal, Manipal Academy of Higher Education, Manipal, India, India.
Muralidhar Varma
Department of Medicine, Kasturba Medical College Manipal, Manipal Academy of Higher Education, Manipal, India, India.
Panretinal photocoagulation in diabetic retinopathy improves oxygen saturation in the retina which
results in regression of neovascularisation. This study is aimed at evaluating the plasma levels of
angiogenic and angiostatic factors after panretinal photocoagulation for retinopathy. Thirty controls
and 29 proliferative diabetic retinopathy subjects who were advised panretinal photocoagulation
were recruited for the study. Plasma was collected both before and four weeks after the last dose of
the therapy and analysed for angiogenic and angiostatic factors using ELISA technique. The plasma
concentration of HIF-1α and VEGF were significantly decreased after laser therapy compared to
baseline levels. The plasma concentration of MMP-9 and PEDF was increased significantly after
photocoagulation. A significant improvement in the visual acuity was also observed following laser
therapy. Panretinal photocoagulation significantly reduced plasma angiogenic and angiostatic
factors. These factors may be used to assess therapeutic outcomes in proliferative retinopathy

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PLASMA LEVELS OF ANGIOGENIC AND ANGIOSTATIC FACTORS AFTER PANRETINAL PHOTOCOAGULATION FOR PROLIFERATIVE DIABETIC RETINOPATHY. (2025). EuroMediterranean Biomedical Journal, 15. https://doi.org/10.3269/1970-5492.2020.15.34
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