Original Articles
Vol. 15 (2020)
https://doi.org/10.3269/1970-5492.2020.15.46
PERFORMANCE OF DIFFUSION KURTOSIS IMAGING FOR CHARACTERIZATION OF PROSTATE LESIONS USING 1.5T MAGNETIC RESONANCE IMAGING SCANNER
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Received: October 16 2025
Published: October 16 2025
Published: October 16 2025
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The aim of the study is to evaluate the diagnostic performance of apparent diffusion coefficient
(ADC) and apparent kurtosis coefficient (Kapp) for the characterization of prostate lesions on 1.5T
MRI. This retrospective study included 34 patients with at least one lesion with PI-RADS score≥ 3.
Performances of ADC and Kapp were evaluated using the Mann-Whitney U test and receiver
operating characteristics curve (AUROC). Lesions with Gleason score≥6 had significantly lower
Kapp compared to benign lesions (p=0.025). The ADC-ratio was the only significantly different
parameter between GS≥7 and GS=6 lesions (p=0.039). Kapp showed the largest AUROC for the
diagnosis of GS≥6 prostate cancers (AUROC: 0.741, p=0.025), while the largest AUROC for the
diagnosis of GS≥7 prostate cancers was achieved by the ADC-ratio (AUROC: 0.709, p=0.039).
While Kapp demonstrated no significant benefit in characterization of prostate cancers compared to
ADC, it could be helpful to distinguish benign lesions from prostate cancers.
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How to Cite
PERFORMANCE OF DIFFUSION KURTOSIS IMAGING FOR CHARACTERIZATION OF PROSTATE LESIONS USING 1.5T MAGNETIC RESONANCE IMAGING SCANNER. (2025). EuroMediterranean Biomedical Journal, 15. https://doi.org/10.3269/1970-5492.2020.15.46
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