RAPIDLY PROGRESSING SYSTEMIC LUPUS ERYTHEMATOSUS IN A YOUNG PATIENT

Abstract

Systemic lupus erythematosus (SLE) has a variable clinical expression and can be manifested by a single

organ or a multiorgan dysfunction. Patients with this condition have higher associated mortality rates, even

when the disease seems clinically stable for many years. An event can occur that deregulates the disease at

any given time, making it active or uncontrolled again. In uncontrolled patients, the diagnosis is sometimes

difficult and both the approach and treatment are crucial for a favorable outcome. This case report describes

the challenging management of a young patient who presented neuropsychiatric manifestations,

hematological abnormalities and a rapid development of multiorgan dysfunction. During the patient’s

hospitalization, three cerebrovascular accidents were registered with a continued worsening of the clinical

status, resulting in her death after 33 days. Even with immunosuppression therapy there were several

complications, some of which were promptly resolved; however, it was not possible to stop a rapidly

progressing autoimmune induced multiorgan failure. The unique features presented by this patient and the

rapid progression of the disease are an important alert for all physicians that work in the emergency room