Original Articles
Vol. 13 (2018)
https://doi.org/10.3269/1970-5492.2018.13.5

COFFEE CONSUMPTION AND FEMALE CANCERS: A NARRATIVE REVIEW OF RECENT EVIDENCE

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Received: October 22 2025
Published: January 12 2026
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Authors

Guido Nicola Zanghì
gzanghi@unict.it
Department of Surgery and Oncology “Policlinico - Vittorio Emanuele” University Hospital, Catania, Italy, Italy.
Nunzio Maria Angelo Rinzivillo
Department of Surgery and Oncology “Policlinico - Vittorio Emanuele” University Hospital, Catania, Italy, Italy.
Stefania Cordova
Department of Surgery and Oncology “Policlinico - Vittorio Emanuele” University Hospital, Catania, Italy, Italy.
Roberto Ciuni
Department of Surgery and Oncology “Policlinico - Vittorio Emanuele” University Hospital, Catania, Italy, Italy.
Vito Leanza
Division of Obstetrics and Gynaecology, Department of Surgery, “Center of Physiopathology of Human Reproduction, S. Bambino University Hospital”, Catania, Italy, Italy.
Coffee contains a wide variety of bioactive compounds including polyphenols, melanoidins, and diterpenes. Coffee consumption may have either neutral or beneficial effects toward human health. In this review, we summarize current evidence regarding the association between coffee consumption and breast, endometrial and ovarian cancer, as well as molecular mechanisms underlying the beneficial effects of coffee. The epidemiological evidence suggests a protective effect of coffee towards postmenopausal breast and endometrial cancer. However, no statistical association was found between coffee and ovarian cancer. The chemo-preventive effects of coffee
phytochemicals may include activation of anti-oxidative and anti-inflammatory response. Finally, coffee bioactive components where shown to inhibit cancer cell proliferation and metastasis, as well as modulation of impaired angiogenesis.

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COFFEE CONSUMPTION AND FEMALE CANCERS: A NARRATIVE REVIEW OF RECENT EVIDENCE. (2026). EuroMediterranean Biomedical Journal, 13. https://doi.org/10.3269/1970-5492.2018.13.5
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