Original Articles
Vol. 13 (2018)
https://doi.org/10.3269/1970-5492.2018.13.15

CONTACT DERMATITIS TO METHYLDIBROMOGLUTARONITRILE: EMERGENCE OF SENSITIZATION IN THE CENTRAL REGION OF TUNISIA

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Received: October 22 2025
Published: January 12 2026
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Authors

Maher Maoua
maouamaher@yahoo.fr
Department of occupational medicine. Dermatology-allergology unit. Teaching hospital Farhat Hached, Sousse, Tunisia, Tunisia.
Haifa Aroui
Department of occupational medicine. Dermatology-allergology unit. Teaching hospital Farhat Hached, Sousse, Tunisia, Tunisia.
Imène Kacem
Department of occupational medicine. Dermatology-allergology unit. Teaching hospital Farhat Hached, Sousse, Tunisia, Tunisia.
Sana Guedri
Department of occupational medicine. Dermatology-allergology unit. Teaching hospital Farhat Hached, Sousse, Tunisia, Tunisia.
Aicha Brahem
Department of occupational medicine. Dermatology-allergology unit. Teaching hospital Farhat Hached, Sousse, Tunisia, Tunisia.
Houda Kalboussi
Department of occupational medicine. Dermatology-allergology unit. Teaching hospital Farhat Hached, Sousse, Tunisia, Tunisia.
Wided Boughattas
Department of occupational medicine. Dermatology-allergology unit. Teaching hospital Farhat Hached, Sousse, Tunisia., Tunisia.
Olfa El Maalel
Department of occupational medicine. Dermatology-allergology unit. Teaching hospital Farhat Hached, Sousse, Tunisia., Tunisia.
Souhaiel Chatti
Department of occupational medicine. Dermatology-allergology unit. Teaching hospital Farhat Hached, Sousse, Tunisia., Tunisia.
Faten Debabbi
Department of occupational medicine. Dermatology-allergology unit. Teaching hospital Farhat Hached, Sousse, Tunisia., Tunisia.
Néjib Mrizak
Department of occupational medicine. Dermatology-allergology unit. Teaching hospital Farhat Hached, Sousse, Tunisia, Tunisia.
Methyldibromoglutaronitrile (MDBGN) is a preservative found in cosmetics as well as in products for industrial use. It caused an outbreak of allergic contact dermatitis in Europe in the 1990s and early 2000s. To assess the prevalence of MDBGN sensitization among consultants in the occupational dermato-allergology unit of Farhat Hached University Hospital in Sousse-Tunisia, we carried out a study of all cases of contact dermatitis to MDBGN confirmed by patch-tests from 1 January 2011 to 31 December 2015. The prevalence of allergic contact dermatitis to MDBGN was 4.5% of all cases of contact dermatitis recorded during the same period with an increase from 1.7% in 2011 to 5.4% in 2015. Associated allergens with contact dermatitis to MDBGN were the Peru balsam in 4 cases, nickel
sulfate and kathon CG in 3 cases each. Contact dermatitis to Dibromodicyanobutane was associated with sensitization to other
preservatives in 4 cases and cosmetic allergens in 6 cases. An increasing rates of sensitization are noticed in our region. The absence of legal restrictions regarding this preservative agent may explain an increase of its use in non-European countries

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CONTACT DERMATITIS TO METHYLDIBROMOGLUTARONITRILE: EMERGENCE OF SENSITIZATION IN THE CENTRAL REGION OF TUNISIA. (2026). EuroMediterranean Biomedical Journal, 13. https://doi.org/10.3269/1970-5492.2018.13.15
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