A REVIEW OF BCR ABL1 NEGATIVE MYELOPROLIFERATIVE NEOPLASM WITH DENTAL IMPLICATIONS

Abstract

BCR-ABL1 negative myeloproliferative neoplasms (MPN) primarily include: Essential thrombocythemia (ET), Polycythemia vera (PV), and Primary myelofibrosis (PMF). They are considered rare hematological malignancies. Lately, with ongoing advances in the field of genetics and molecular biology, more clarity has been achieved on the pathogenesis of these disorders and many advances are being made in the diagnosis, prognostic evaluation and treatment of these malignancies. These disorders have oral manifestations and also present a significant risk of bleeding and thrombosis after dental procedures if proper precautions and care are not taken. This article highlights important aspects of these disorders including oral manifestations and dental care.