Original Articles
Vol. 16 (2021)

CONTRAST-ENHANCEMENT ULTRASOUND WITH MICROBUBBLES FOR SENTINEL NODE IDENTIFICATION: A CASE REPORT

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Published: October 15 2025
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Marco Materazzo
Breast Unit, Department of Surgical Science, Policlinico Tor Vergata University, Rome, Italy., Italy.
Marco Pellicciaro
marcopell62@gmail.com
Breast Unit, Department of Surgical Science, Policlinico Tor Vergata University, Rome, Italy, Italy.
Cataldo Caruso
Breast Unit, Department of Surgical Science, Policlinico Tor Vergata University, Rome, Italy, Italy.
Andrea Farinaccio
Department of Emergency and Admission, Critical Care Medicine, Pain Medicine and Anesthetic Science, Policlinico Tor Vergata University, Rome, Italy., Italy.
Mattia De Riso
Department of Clinical Sciences and Translational Medicine, University of Rome Tor Vergata, Rome, Italy, Italy.
Francesca Santori
Breast Unit, Department of Surgical Science, Policlinico Tor Vergata University, Rome, Italy, Italy.
Chiara Adriana Pistolese
Department of Biomedicine and Prevention, Policlinico Tor Vergata (PTV) University, Rome, Italy, Italy.
Tommaso Perretta
Department of Biomedicine and Prevention, Policlinico Tor Vergata (PTV) University, Rome, Italy, Italy.
Rosaria Meucci
Department of Biomedicine and Prevention, Policlinico Tor Vergata (PTV) University, Rome, Italy, Italy.
Agostoino Chiaravalloti
Department of Biomedicine and Prevention, Policlinico Tor Vergata (PTV) University, Rome, Italy; Nuclear Medicine Section, IRCCS Neuromed, Pozzilli, Italy., Italy.
Gianluca Vanni
Breast Unit, Department of Surgical Science, Policlinico Tor Vergata University, Rome, Italy., Italy.
Lymph node (LN) stage remains the primary prognostic discriminant in breast cancer. Lymphatic mapping with sentinel LN (SLN) represents the gold standard for axillary staging in early breast cancer (EBC), thus identification of a new contrast agent could provide clinicians with an alternative to blue dye. AX-CES 1.2020, a prospective non-inferiority phase III trial designed to evaluate the use of Sonovue (microbubbles with sulphur hexafluoride) under contrast enhanced ultrasound (CEUS) as a SLN contrast agent. We herein present the first patient enrolled in the AX CES 1.2020 trial. In the present clinical report, CEUS-SLN was a safe and feasible technique that enhanced the same LN identified by m99Tc. Larger series are needed in order to investigate the role of CEUS-SLN in EBC and further studies could evaluate the combination of the pathological and ultrasonographic features of CEUS-SLN to predict axillary involvement.

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CONTRAST-ENHANCEMENT ULTRASOUND WITH MICROBUBBLES FOR SENTINEL NODE IDENTIFICATION: A CASE REPORT. (2025). EuroMediterranean Biomedical Journal, 16. https://doi.org/10.3269/ebmj.2021.90
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