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Vol. 15 (2020)

SERUM HSP 70 LEVELS OF CHRONIC HEPATITIS B PATIENTS ARE SUBSTANTIALLY CORRELATED WITH HBsAg

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Published: October 16 2025
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Awaz A. Saadi
awaz.arshad@uod.ac
Biology Department, University of Duhok, Kurdistan, Iraq, Iraq.
Ahmed M. Salih
Duhok Medical Research Centre, College of Medicine, University Of Duhok, Kurdistan, Iraq, Iraq.
Muayed A. Merza
Azadi Teaching Hospital, Department of internal medicine, University of Duhok, Kurdistan, Iraq, Iraq.
Heat-shock protein 70 (HSP70) is a stress-induced protein that demonstrates the anti-apoptosis response that ensures the survival of cells. The aim of this study is to investigate the significant correlation of serum HSP70 levels in chronic hepatitis B viral infection (HBV) patients. The study was performed on fifty-three chronic HBV patients from June–December 2015. HBV-DNA, HBsAg, HBeAg, and anti HBeAb, ALT, AST, ALP, and AFP levels were determined. Serum HSP70 level was estimated for positive HBV patients. The results showed a significant correlation between HSP70 [mean of 41.325±29.7206], HBsAg [mean of 12074.93±5681.619] at p=0.006 [P=or <0.01], and also between HBV DNA [3.2E+10±2.4E+11] and HBeAg [96454.29321±300533.25] at P=0.002 [P= or <0.05]. The expression of HSP70 is increased significantly with the increase of HBsAg titre, which together may work as indicators of chronic HBV infection.

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SERUM HSP 70 LEVELS OF CHRONIC HEPATITIS B PATIENTS ARE SUBSTANTIALLY CORRELATED WITH HBsAg. (2025). EuroMediterranean Biomedical Journal, 15. https://doi.org/10.3269/ebmj.2020.139
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