SERUM HSP 70 LEVELS OF CHRONIC HEPATITIS B PATIENTS ARE SUBSTANTIALLY CORRELATED WITH HBsAg

Abstract

Heat-shock protein 70 (HSP70) is a stress-induced protein that demonstrates the anti-apoptosis

response that ensures the survival of cells. The aim of this study is to investigate the significant

correlation of serum HSP70 levels in chronic hepatitis B viral infection (HBV) patients. The study

was performed on fifty-three chronic HBV patients from June–December 2015. HBV-DNA,

HBsAg, HBeAg, and anti HBeAb, ALT, AST, ALP, and AFP levels were determined. Serum

HSP70 level was estimated for positive HBV patients. The results showed a significant correlation

between HSP70 [mean of 41.325±29.7206], HBsAg [mean of 12074.93±5681.619] at p=0.006

[P=or <0.01], and also between HBV DNA [3.2E+10±2.4E+11] and HBeAg

[96454.29321±300533.25] at P=0.002 [P= or <0.05]. The expression of HSP70 is increased

significantly with the increase of HBsAg titre, which together may work as indicators of chronic

HBV infection.