Reviews
Vol. 15 (2020)
https://doi.org/10.3269/1970-5492.2020.15.20
SERUM HSP 70 LEVELS OF CHRONIC HEPATITIS B PATIENTS ARE SUBSTANTIALLY CORRELATED WITH HBsAg
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Received: October 15 2025
Published: October 16 2025
Published: October 16 2025
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Heat-shock protein 70 (HSP70) is a stress-induced protein that demonstrates the anti-apoptosis
response that ensures the survival of cells. The aim of this study is to investigate the significant
correlation of serum HSP70 levels in chronic hepatitis B viral infection (HBV) patients. The study
was performed on fifty-three chronic HBV patients from June–December 2015. HBV-DNA,
HBsAg, HBeAg, and anti HBeAb, ALT, AST, ALP, and AFP levels were determined. Serum
HSP70 level was estimated for positive HBV patients. The results showed a significant correlation
between HSP70 [mean of 41.325±29.7206], HBsAg [mean of 12074.93±5681.619] at p=0.006
[P=or <0.01], and also between HBV DNA [3.2E+10±2.4E+11] and HBeAg
[96454.29321±300533.25] at P=0.002 [P= or <0.05]. The expression of HSP70 is increased
significantly with the increase of HBsAg titre, which together may work as indicators of chronic
HBV infection.
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SERUM HSP 70 LEVELS OF CHRONIC HEPATITIS B PATIENTS ARE SUBSTANTIALLY CORRELATED WITH HBsAg. (2025). EuroMediterranean Biomedical Journal, 15. https://doi.org/10.3269/1970-5492.2020.15.20
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