STUDY OF ASSOCIATION BETWEEN IGF-1 GENE POLYMORPHISM AND OBESE ADULTS IN BABYLON GOVERNORATE

Abstract

The aims of the present study were to determine the association between IGF-1gene polymorphism with obese individuals. This case control analysis was performed on 50 subjects ,obese (n=30) and control (n=20) groups for age ranged (20-40 year). The results showed that genotype distribution of AA and AB in IGF-1 gene polymorphism were 83.3% and 16.7% respectively in the patients of obese group, while was 90.0% and 10.0% respectively in the control group .Meantime the allele frequency of A and B in IGF-1 gene polymorphism were 91.65% and 8.35% respectively in obese group, whereas it was 95.0% and 5.0% respectively in the control group. Several single nucleotide polymorphisms (SNPs), was obtained between the two resolved haplotypes and between the IGF1 gene, exon3 Primer3 plus reference of the study. The results demonstrate that there is no association between AA and AB polymorphisms with in obese (OR=0.87,CI[0.71-1.17]) as in comparison with control groups.