DESFLURANE OR SEVOFLURANE ADMINISTRATION WITH LARINGEAL MASK AIRWAY (LMA®) DURING MEDICALLY ASSISTED FECUNDATION IN “DAY SURGERY ANESTHESIA”

Aims: To evaluate desflurane and sevoflurane effects on recovery-discharge times of patients ventilated by laryngeal mask during day surgery anesthesia. Methods: 40 patients, ASA physical status I, candidate to medically assisted fecundation, were randomly assigned to group D or S, to receive desflurane or sevoflurane in a 02/air 50% mixture in closed circuit 4L/min respectively. After intubation, inhalating agents administration started at 6% and 2% concentration for desflurane and sevoflurane respectively. Then inhalating agents were titrated to achieve a Narcotrend Index score of D0-1, indicating adequate level of anesthesia. At the end of surgery patients were transported into recovery room were following parameters were registered: time to eyes opening, time to orientating. Results: Mean end tidal concentration to and 10 min after induction was 4.4% for group D and 1.8% for group S. Hemodynamic variables were similar in both groups. Airway adverse events occurred (hiccup/coughing: 8/6 cases group D, 6/3 cases group S) but any case of laringospasm was observed. Times of recovery resulted faster in group D (p<0.001) but no differences were observed for time of discharge from the hospital. Conclusions: Our data suggest that desflurane could be considered a good choice and a safe agent for this kind of surgical procedure for the reduction of recovery-discharge times, patients comfort and hemodynamic stability, even if it is responsible of more airway adverse event than sevoflurane. More investigations are required to validate the use of desfluarne in such anesthesiological practice.