Borys M. Filenko, Ivan I. Starchenko, Natalia V. Roiko, Svitlana M. Sovhyria, Valentyna V. Cherniak, Oleksandr P. Khazanov
The mortality rate in gastric cancer during pregnancy is very high, which dictates the need to research and improve the methods of early diagnosis of malignancies, as well as studying the pathogenesis of malignant tumors in pregnant women. We report a lethal case of gastric cancer in a pregnant woman. The findings of the autopsy, histological, histochemical and immunohistochemical examinations verified gastric signet ring cells carcinoma with multiple metastases and infiltration of the placental intervillous space. The possible pathogenesis of cancer with changes in the hormonal background occurring in pregnant women is discussed. Understanding the endocrine mechanisms of carcinoma pathogenesis will be useful for developing new therapies for gastric cancer.