EFFICACY OF PLATELET-RICH PLASMA IN EXPERIMENTAL INSTRUMENTED INTERBODY SPINAL FUSION

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This study aimed to analyze the influence of Platelet-Rich Plasma (PRP) on bone growth in experimental instrumented interbody spinal fusion (IISF). 16 adult sheep underwent IISF at L3–L4 level using a cylindrical threaded expanding titanium cage with morselized iliac crest cancellous autograft. In 8 animals (Group I) this was augmented with PRP, in the remaining 8 (Group II), it was not. Ra-diographs of the spine were taken preoperatively and at 1, 3, and 6 months, moreover autoptic vertebral samples were obtained and evaluated histologically and by CT scan at 8 months.
Histological analysis revealed more evident new bone formation with bony bridge into the cages in Group I than Group II. There were relevant differences be-tween the groups with regard to interbody fusion calculated using trabecular bone score (p<0.05).

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