Gabriele Busè, Roberto Cannella, Alberto Bruno, Claudio Leto, Giuseppe Cutaia, Leonardo Salvaggio, Vincenzo Costanzo, Dario Giambelluca, Marcella Ferraro, Federica Vernuccio,Giorgio Collura, Cesare Gagliardo, Maurizio Marrale, Massimo Midiri, Massimo Galia, Giuseppe Salvaggio
The aim of the study is to evaluate the diagnostic performance of apparent diffusion coefficient (ADC) and apparent kurtosis coefficient (Kapp) for the characterization of prostate lesions on 1.5T MRI. This retrospective study included 34 patients with at least one lesion with PI-RADS score≥ 3. Performances of ADC and Kapp were evaluated using the Mann-Whitney U test and receiver operating characteristics curve (AUROC). Lesions with Gleason score≥6 had significantly lower Kapp compared to benign lesions (p=0.025). The ADC-ratio was the only significantly different parameter between GS≥7 and GS=6 lesions (p=0.039). Kapp showed the largest AUROC for the diagnosis of GS≥6 prostate cancers (AUROC: 0.741, p=0.025), while the largest AUROC for the diagnosis of GS≥7 prostate cancers was achieved by the ADC-ratio (AUROC: 0.709, p=0.039). While Kapp demonstrated no significant benefit in characterization of prostate cancers compared to ADC, it could be helpful to distinguish benign lesions from prostate cancers.