PHOSPHONATED ISOXAZOLIDINYL NUCLEOSIDES: A NEW CLASS OF MODIFIED NUCLEOSIDES

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This review offers an overview of the synthesis of phosphonated isoxazolidinyl nucleo-sides, a new class of interesting and potentially antiviral/antitumor agents. The synthetic methodology relies on a 1,3-dipolar cycloaddition reaction as a key step. The cycloaddi-tion process involves substituted nitrones, phosphonated nitrones, or nitrones containing functional groups easily convertible into a phosphonated group. Biological assays are pre-sented, which show that phosphonated isoxazolidinyl nucleosides represent a new prom-ising template of nucleoside analogues.

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