Wednesday, September 18
LAST ISSUE
Embj
You are at:»»PHOSPHONATED ISOXAZOLIDINYL NUCLEOSIDES: A NEW CLASS OF MODIFIED NUCLEOSIDES

PHOSPHONATED ISOXAZOLIDINYL NUCLEOSIDES: A NEW CLASS OF MODIFIED NUCLEOSIDES

0
By on Embj

This review offers an overview of the synthesis of phosphonated isoxazolidinyl nucleo-sides, a new class of interesting and potentially antiviral/antitumor agents. The synthetic methodology relies on a 1,3-dipolar cycloaddition reaction as a key step. The cycloaddi-tion process involves substituted nitrones, phosphonated nitrones, or nitrones containing functional groups easily convertible into a phosphonated group. Biological assays are pre-sented, which show that phosphonated isoxazolidinyl nucleosides represent a new prom-ising template of nucleoside analogues.

Share.

About Author

Related Posts

Leave A Reply