Carmelo Saraniti, Salvatore Gallina, Manuela Santangelo, Francesca Montana, Francesca Portelli , Elisabetta Orlando
Respiratory Epithelial Adenomatoid Hamartoma (REAH) is a rare benign lesion that may occur in the nasal cavity and paranasal sinuses. Histology is essential for the differential diagnosis with other lesions that could affect the sinonasal region. Our report focuses on three cases of male patients that were 46, 66 and 73 years old, diagnosed with REAH of the sinonasal region. All cases presented a nasal obstruction and hyposmia, and in one case cephalalgia. The definitive diagnosis of REAH was supported by the endoscopic, radiological and histological examinations. The patients underwent surgical excision with an endoscopic approach and did not experience a local recurrence at the time of writing this manuscript. REAH is a rare and often unrecognized clinical condition. The gold standard for treatment is complete surgical excision, which also allows for a correct histological diagnosis. Recurrence after surgery was not reported in our findings, as described in the literature.